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Vidal R, Blanco I, Casas F, Jardi R, Miravitlles M.
Diagnóstico y tratamiento del déficit de alfa-1antitripsina.
Arch Bronconeumol 2006 Dec;42(12):645-59. www.archbronconeumol.org
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Rodriguez F, de la Roza C, Jardi R, Schaper M, Vidal R, Miravitlles M.
Glutathione S-Transferase P1 and Lung Function in Patients With alpha 1- antitrypsin deficiency and COPD.
Chest. 2005;127(5):1537-43.
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De la Roza C, Costa X, Vidal R, Vila S, Rodriguez-Frias F, Jardi R, Miravitlles M.
Screening program for alpha-1 antitrypsin deficiency in patients with chronic obstructive pulmonary disease, using dried blood spots on filter paper.
Arch Bronconeumol. 2003;39(1):8-12.
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Miravitlles M, Vilà S, Torrella M, Balcells E, Rodríguez-Frías, de la Roza C, Jardí R, Vidal R.
Influence of deficient alpha-1-antitrypsin phenotypes on clinical characteristics and severity of asthma in adults.
Respir Med 2002; 96: 186-192.
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Rodríguez F, Jardí R, Costa X, Cotrina M, Galimany R, Vidal R, Miravitlles M.
Rapid screening for alpha-1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood spots.
Am J Respir Crit Care Med 2002; 166: 814-817.
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Luisetti M, Miravitlles M, Stockley RA.
Alpha-1-antitrypsin deficiency: a report from the 2nd meeting of the Alpha One International Registry, Rapallo (Genoa, Italy), 2001.
Eur Respir J 2002; 20: 1050-1056.
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Jardí R, Rodríguez-Frías F, Lopez-Talavera JC, Miravitlles M, Cotrina M, Costa X, Pascual C, Vidal R.
Characterization of the new alpha-1-antitrypsin deficient PI M-type allele, PI Mvall d'hebron (Pro369-Ser).
Human Hered 2000; 50; 320-321.
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Costa X, Jardí R, Rodríguez F, Miravitlles M, Cotrina M, Pascual C, Vidal R.
Easy method for screening dried blood spot specimens on filter paper for alpha-1 antitrypsin deficiency.
Eur Respir J 2000; 15: 1111-1115.
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Miravitlles M.
Alpha-1-antitrypsin deficiency: epidemiology and prevalence.
Respir Med 2000; 94 (Suppl C): S12-S15.
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Blanco I, Bustillo EF, Rodríguez MC.
a1-antitrypsin PI phenotypes S and Z in Europe: an analysis of the published surveys.
(In press)
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Blanco I, Bustillo EF, Rodríguez MC.
Distribution of a1-antitrypsin PI S and PI Z frequencies in countries outside Europe: a meta-analysis. Clin Genet 2001; 60: 000-000 (In press).
Received 31 July 2001; revised and accepted for publication 26 September 2001
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Miravitlles M, de Gracia J, Rodrigo MJ, Cruz MJ, Vendrell M, Vidal R, Morell F.
Specific antibody response against the 23-valent pneumococcal vaccine in patients with alpha-1-antitrypsin deficiency with and without bronchiectasis.
Chest 1999; 116: 946-952.
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Miravitlles M, Vidal R, Barros-Tizón JC, Bustamante A, España PP, Casas F, Martínez MT, Escudero C, Jardí R.
Estado actual del tratamiento sustitutivo en el enfisema congénito por déficit de alfa-1-antitripsina. Informe del registro nacional.
Arch Bronconeumol 1999; 35: 446-454.
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Blanco I, Fernández E, Rodríguez MC, Fernández A.
Frecuencias alélicas del gen de la alfa-1-antitripsina en la población general de una comarca de Asturias.
Med Clin (Barc) 1999; 133: 366-370.
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Miravitlles M, Vidal R, Barros-Tizón JC, Bustamante A, España PP, Casas F, Martínez MT, Escudero C, Jardí R.
Usefulness of a national Registry of alpha-1-antitrypsin deficiency. The Spanish experience.
Respir Med 1998; 92: 1181-1187.
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Vidal R, Miravitlles M y Grupo de Estudio del déficit de alfa-1-antitripsina.
Informe del Registro Español de Pacientes con déficit de alfa-1-antitripsina.
Arch Bronconeumol 1995; 31: 299 -302.
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Tirado-Conde G., Lara B., Miravitlles M.
Augmentation therapy for emphysema due to alpha-1 antitrypsin deficiency.
Therapeutic Advances in Respiratory disease. 2008:2(1);13-21. http://tar.sagepub.com
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De Serres, Balnco I, Fernández-Bustillo E.
PIS and PIZ alpha-1 antitrypsin deficiency worldwide. A review of existing genetic epidemiological data.
Monaldi Arch Chest Dis 2007;67(4): 184-208.
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Lara B., de la Roza C., Vilà S., Vidal R., Miravitlles M.
Development and results of the Spanish Registry of patients with alpha-1-antitrypsin deficiency.
Int J COPD 2007:2(3);1-6.
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Soy D., De la Roza C., Lara B., Esquinas C., Torres A., Miravitlles M.
Alpha-1-antitrypsin deficiency: optimal therapeutic regime based on population pharmacokinetics.
Thorax 2006 Dec; 61(12):1059-64.
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De Serres FJ, Blanco I, Fernandez-Bustillo E.
Estimating the risk for alpha-1 antitrypsin deficiency among COPD patients: evidence supporting targeted screening.
COPD 2006;3(3):133-9.
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Blanco I, De Serres FJ, Fernandez-Bustillo E, Lara B, Miravitlles M.
Estimated numbers and prevalence of PI*S and PI*Z alleles for alpha-1 antitrypsin deficiency in European countries.
Eur Respìr J.2006;27(1):77-84.
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Blanco I., de Serres FJ, Fernández-Bustillo E., Lara B., Miravitlles M.
Estimated numbers and prevalence of PI*S and PI*Z alleles of alpha-1-antitrypsin deficiency in European countries.
Eur Resp J 2006 Jan;27(1): 77-84.
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De la Roza C., Lara B., Vilà S., Miravitlles M.
Déficit de alfa-1 antitripsina: situación en España y desarrollo de un programa de detección de casos.
Arch Bronconeumol 2006 Jun;42(6):290-8.
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De la Roza C., Rodriguez-Frias F., Lara B., Vidal R., Miravitlles M.
Results of a case-detection programme for alpha-1-antitrypsin deficiency in COPD patients.
Eur Respir J. 2005 Oct;26(4):616-22.
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Gompertz S, Hill AT, Bayley DL, Stockley RA.
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Respir Med. 2005 Oct 26
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Stolk J.
Case detection of alpha-1-antitrypsin deficiency: does it help the patient or the doctor?
Eur Respir J. 2005 Oct;26(4):561-2.
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Strange C, Stoller JK, Sandhaus RA, Dickson R, Turino G.
Results of a Survey of Patients with Alpha-1 Antitrypsin Deficiency.
Respiration. 2005 Aug 23
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Needham M, Stockley RA.
Exacerbations in alpha-1-antitrypsin deficiency.
Eur Respir J. 2005 Jun;25(6):992-1000.
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Rodriguez F, de la Roza C, Jardi R, Schaper M, Vidal R, Miravitlles M.
Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD.
Chest. 2005 May;127(5):1537-43.
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Stoller JK, Tomashefski J Jr, Crystal RG, Arroliga A, Strange C, Killian DN, Schluchter MD, Wiedemann HP.
Mortality in individuals with severe deficiency of alpha1-antitrypsin: findings from the National Heart, Lung, and Blood Institute Registry.
Chest. 2005 Apr;127(4):1196-204.
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De Serres FJ, Blanco I, Fernandez-Bustillo E.
Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World.
Genet Med. 2005 Mar;7(3):175-84. Review.
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Abboud RT, Ford GT, Chapman KR.
Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome?.
Treat Respir Med. 2005;4(1):1-8
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Blanco I, Fernández-Bustillo E, De Serres FJ, Alkassam D, Rodríguez C.
PI*S yPI*Z: prevalencia estimada y número de sujetosdeficientes en España.
Med Clin (Barc) 2004 Dic 4; 123(20):761-5.
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ATS/ERS statement: Standars for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency.
Am J Respir Crit Care Med 2003;168:820-900.
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Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DCS, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, Vrooman HA, Reiber JHC, Hansen NC, Heckscher T, Viskum K, Stolk J.
A Randomized Clinical Trial of 1-Antitrypsin Augmentation Therapy.
Am. J. Respir. Crit. Care Med., 1999; 160: 1468-1472.
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Blanco I, Fernández E, Rodríguez MC, Fernández A.
Allelic frequency of the gene of alpha-1-antitrypsin in the general population in a county in Asturias.
Med Clin (Barc) 1999; 113(10): 366-70.
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Alpha-1-Antitrypsin Deficiency Registry Study Group.
Survival and FEV1 decline in individuals with severe deficiency of alpha-1-antitrypsin.
Am J Respir Crit Care Med 1998;158:49-59.
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Miravitlles M.
¿Debemos administrar tratamiento sustitutivo a los pacientes con déficit de alfa-1-antitripsina? (editorial).
Arch Bronconeumol 1998; 34: 109-111.
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McElvaney N, Stoller J, Buist A, et al.
Baseline characteristics of enrollees in the National Heart, Lung and Blood Insitute registry of alpha-1-antitrypsin deficiency.
Chest 1997; 111:394-403.
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Stoller J, Buist A, Burrows B, et al.
Quality control of spirometry testing in the registry of patients with severe alpha-1-antitrypsin deficiency.
Chest 1997; 111: 899-909.
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Pierce JA.
Alpha-1-Antitrypsin augmentation therapy (editorial).
Chest 1997; 112, 4.
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Seersholm N, Wencker M, et al.
Does alpha-1-antitrypsin augmentation therapy slow the annual decline in FEVI in patients with severe hereditary alpha-1-antittypsin deficiency?
Eur Respir J 1997; 10: 2260-3.
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Jardí R, Rodríguez-Frías F, Casas F, Cotrina M, Vidal R, Miravitlles M, Pascual C.
Caracterización molecular de dos variantes deficitarias de la alfa-1-antitripsina: PI Mpalermo y PI Plovel.
Med Clin (Barc) 1997; 109: 463-466.
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Siofakos NM, Vermiere P, Pride NB, et al.
Optimal treatment and management of chronic obstructive pulmonary disease (COPD).
Eur Resp J 1995; 8: 1398-1420.
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Alpha-1-Antitrypsin Deficiency Registry Study Group.
A registry of patients with severe deficiency of alpha-1-antitrypsin: design and methods.
Chest 1994; 106:1223-32.
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